Ethanolic extract of gabirobeira (Campomanesia adamantium) leaves reduces proliferation of osteosarcoma cells in vitro

Osteosarcoma is the most commonly diagnosed malignant bone tumor in humans, with a higher incidence children and young people. It highly aggressive has high metastatic potential. Its treatment based on both chemotherapy surgical intervention. However, currently used chemotherapeutic agents, such as doxorubicin, have several adverse effects patient. Therefore, there growing demand for new agents that stimulate researches, those involving compounds extracted from plants, gabirobeira. In this study, we aimed to evaluate cytotoxic of ethanolic extract, crude ethyl acetate, gabirobeira leaves osteosarcoma cells vitro. Cytotoxicity was evaluated using Trypan blue exclusion method IC50 values were calculated tetrazolium reduction method. The extract showed effect group treated at 1. 0μL mL-1 concentration 48 hours cytotoxicity lowest value found 24 interval. cells.